Replacement of Pantothenic Acid by Panthenol in Chick Diets

The pantothenic acid content of coenzyme A by chick assay.

Lipmann, Kaplan, Novelli, Tuttle, and Guirard (1) reported that, whereas concentrates of the coenzyme required for acetylation (coenzyme A) showed no pantothenic acid activity by the ordinary microbiological assay, considerable amounts of p-alanine were found after acid hydrolysis. From this early observation, it was suspected that the coenzyme might contain combined pantothenic acid which was ...

The availability to the chick of pantothenic acid in foods.

1. The content of total pantothenic acid (PaA) in two foodstuffs of microbial origin was measured by standard microbiological and chick biological assays. 2. Substantially and consistently higher values were found by the chick assay than by the microbiological determination, indicating that PaA-containing compounds were present that were not utilized by the test micro-organisms but were availab...

The effects of high dietary supplements of copper sulphate on pantothenic acid metabolism in the chick.

1. The effects of incorporation of copper sulphate supplying 250 mg copper/kg semi-purified diet with graded amounts of calcium pantothenate (CaPa) were studied in chicks. 2. When the doses of CaPa were marginally adequate or less the Cu supplementation induced severe signs of pantothenic acid (PaA) deficiency. 3. Livers of the Cu-treated birds given low doses of PaA had lower concentrations of...

Pantothenic acid synthesis by smooth Brucella abortus.

The relationship between formation of exogenous alanine and the establishment of nonsmooth variants in originally smooth cultures of Brucella abortus strains has been clearly demonstrated (Goodlow et al., 1950). Furthermore, the addition of D-alanine to smooth cultures in synthetic medium (Gerhardt and Wilson, 1948) results in earlier establishment of nonsmooth cells (Goodlow et al., 1951). Sub...

Microbic Decomposition of Pantothenic Acid.